{"id":83,"date":"2020-04-15T11:15:45","date_gmt":"2020-04-15T14:15:45","guid":{"rendered":"http:\/\/projects.upei.ca\/murphylab\/?page_id=83"},"modified":"2020-06-18T21:41:00","modified_gmt":"2020-06-19T00:41:00","slug":"small-molecule-function","status":"publish","type":"page","link":"http:\/\/projects.upei.ca\/murphylab\/small-molecule-function\/","title":{"rendered":"Immune Cell Metabolism"},"content":{"rendered":"\n<p>Our understanding of immune cell metabolism (e.g. T cell and macrophage subsets) is constantly increasing. We continue to gain a deeper appreciation for production of \u201cimmunometabolites\u201d such as itaconate and succinate, their function, and how they change during the differentiation of immune cell subsets<sup>1,2<\/sup>. Our lab is interested in exploring the function of these immunometabolites and other intermediates of secondary metabolic pathways commonly found to be regulated in macrophages and other immune cells. &nbsp;<\/p>\n\n\n\n<ol type=\"1\"><li>Giacomantio MA, Sterea AM, Kim Y, Paulo JA, Clements DR, Kennedy BE, Bydoun MJ, Waisman DM, Gygi SP, Giacomantonio CA, <strong>Murphy JP<\/strong><sup>##<\/sup>, Gujar S<sup>##<\/sup>. (2020). Quantitative proteome responses to oncolytic reovirus in GM-CSF and M-CSF-differentiated bone marrow-derived cells. <em>J. Proteome Res<\/em>. 19(2):708-718.<\/li><li>Clements D, <strong>Murphy JP<\/strong>, Sterea A, Kennedy BE, Kim Y, Helson E, Almasi S, Holay N, Konda P, Paulo JA, Sharif T, Lee PW, Weekes MP, Gygi SP, Gujar S. (2017). Quantitative temporal <em>in vivo <\/em>proteomics deciphers the transition of virus-driven myeloid cells into M2 macrophages<em>. J. Proteome Res.<\/em>16(9): 3391-3406.<\/li><\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Our understanding of immune cell metabolism (e.g. T cell and macrophage subsets) is constantly increasing. We continue to gain a deeper appreciation for production of \u201cimmunometabolites\u201d such as itaconate and succinate, their function, and how they change during the differentiation of immune cell subsets1,2. Our lab is interested in exploring [&hellip;]<\/p>\n","protected":false},"author":228,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"jetpack_post_was_ever_published":false,"footnotes":""},"tags":[],"jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/PbTVHA-1l","_links":{"self":[{"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/pages\/83"}],"collection":[{"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/users\/228"}],"replies":[{"embeddable":true,"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/comments?post=83"}],"version-history":[{"count":4,"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/pages\/83\/revisions"}],"predecessor-version":[{"id":289,"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/pages\/83\/revisions\/289"}],"wp:attachment":[{"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/media?parent=83"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/projects.upei.ca\/murphylab\/wp-json\/wp\/v2\/tags?post=83"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}