PUBLICATIONS

(1)         Lin, F.; Recchia, M. J. J.; Clark, T. N.; Kennelly, E. J.; Linington, R. G.; Long, C. Metabolite Profiling and Characterization of Potential Anticancer Constituents from Garcinia Subfalcata Using UPLC-IMS-QTOF-MS. Food Chem. 2025, 465, 141900. https://doi.org/https://doi.org/10.1016/j.foodchem.2024.141900.

(2)         Khadilkar, A.; Bunch, Z. L.; Wagoner, J.; Ravindran, V.; Oda, J. M.; Vidar, W. S.; Clark, T. N.; Manwill, P. K.; Todd, D. A.; Barr, S. A.; Olinger, L. K.; Fink, S. L.; Strangman, W. K.; Linington, R. G.; MacMillan, J. B.; Cech, N. B.; Polyak, S. J. Modulation of in Vitro SARS-CoV-2 Infection by Stephania Tetrandra and Its Alkaloid Constituents. J. Nat. Prod. 2023, 86 (4), 1061–1073. https://doi.org/10.1021/acs.jnatprod.3c00159.

(3)         Morehouse, N. J.; Clark, T. N.; McMann, E. J.; van Santen, J. A.; Haeckl, F. P. J.; Gray, C. A.; Linington, R. G. Annotation of Natural Product Compound Families Using Molecular Networking Topology and Structural Similarity Fingerprinting. Nat. Commun. 2023, 14 (1), 308. https://doi.org/10.1038/s41467-022-35734-z.

(4)         Morehouse, N. J.; Clark, T. N.; Kerr, R. G.; Johnson, J. A.; Gray, C. A. Caryophyllene Sesquiterpenes from a Chaetomium Globosum Endophyte of the Canadian Medicinal Plant Empetrum Nigrum. J. Nat. Prod. 2023, 86 (6), 1615–1619. https://doi.org/10.1021/acs.jnatprod.2c01159.

(5)         Hight, S. K.; Clark, T. N.; Kurita, K. L.; McMillan, E. A.; Bray, W.; Shaikh, A. F.; Khadilkar, A.; Haeckl, F. P. J.; Carnevale-Neto, F.; La, S.; Lohith, A.; Vaden, R. M.; Lee, J.; Wei, S.; Lokey, R. S.; White, M. A.; Linington, R. G.; MacMillan, J. B. High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling. Proc. Natl. Acad. Sci. 2022, 119 (49), e2208458119. https://doi.org/10.1073/pnas.2208458119.

(6)         Carnevale Neto, F.; Clark, T. N.; Lopes, N. P.; Linington, R. G. Evaluation of Ion Mobility Spectrometry for Improving Constitutional Assignment in Natural Product Mixtures. J. Nat. Prod. 2022, 85 (3), 519–529. https://doi.org/10.1021/acs.jnatprod.1c01048.

(7)         Clark, T. N.; Houriet, J.; Vidar, W. S.; Kellogg, J. J.; Todd, D. A.; Cech, N. B.; Linington, R. G. Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability. J. Nat. Prod. 2021, 84 (3), 824–835. https://doi.org/10.1021/acs.jnatprod.0c01376.

(8)         van Santen, J. A.; Poynton, E. F.; Iskakova, D.; McMann, E.; Alsup, T. A.; Clark, T. N.; Fergusson, C. H.; Fewer, D. P.; Hughes, A. H.; McCadden, C. A.; Parra, J.; Soldatou, S.; Rudolf, J. D.; Janssen, E. M.-L.; Duncan, K. R.; Linington, R. G. The Natural Products Atlas 2.0: A Database of Microbially-Derived Natural Products. Nucleic Acids Res. 2022, 50 (D1), D1317–D1323. https://doi.org/10.1093/nar/gkab941.

(9)         Liang, L.; Haltli, B.; Marchbank, D. H.; Fischer, M.; Kirby, C. W.; Correa, H.; Clark, T. N.; Gray, C. A.; Kerr, R. G. Discovery of an Isothiazolinone-Containing Antitubercular Natural Product Levesquamide. J. Org. Chem. 2020, 85 (10), 6450–6462. https://doi.org/10.1021/acs.joc.0c00339.

(10)      Van Santen, J. A.; Jacob, G.; Singh, A. L.; Aniebok, V.; Balunas, M. J.; Bunsko, D.; Neto, F. C.; Castaño-Espriu, L.; Chang, C.; Clark, T. N.; Cleary Little, J. L.; Delgadillo, D. A.; Dorrestein, P. C.; Duncan, K. R.; Egan, J. M.; Galey, M. M.; Haeckl, F. P. J.; Hua, A.; Hughes, A. H.; Iskakova, D.; Khadilkar, A.; Lee, J.-H.; Lee, S.; Legrow, N.; Liu, D. Y.; Macho, J. M.; McCaughey, C. S.; Medema, M. H.; Neupane, R. P.; O’Donnell, T. J.; Paula, J. S.; Sanchez, L. M.; Shaikh, A. F.; Soldatou, S.; Terlouw, B. R.; Tran, T. A.; Valentine, M.; Van Der Hooft, J. J. J.; Vo, D. A.; Wang, M.; Wilson, D.; Zink, K. E.; Linington, R. G. The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. ACS Cent. Sci. 2019, 5 (11). https://doi.org/10.1021/acscentsci.9b00806.

(11)        Clark, T. N.; Carroll, M.; Ellsworth, K.; Guerrette, R.; Robichaud, G. A.; Johnson, J. A.; Gray, C. A. Antibiotic Mycotoxins from an Endophytic Fusarium Acuminatum Isolated from the Medicinal Plant Geum Macrophyllum. Nat. Prod. Commun. 2018, 13 (10).

(12) Mullin T.; Clark T.N.; Johnson J.A.; and Gray C.A. Isolation of Phomopsolide A as the antimycobacterial constituent of an unidentified endophyte of the Canadian medicinal plant geum macrophyllum. Canadian journal of undergraduate research. February 2017: 69-71.

(13)      Clark  F; Calhoun, L; Boland, P; Kerr, R; Johnson, JA; Gray, CA, T. B. A Comparison between the Application of NMR and LC-HRMS Based Metabolomics on the Discovery of Natural Products from Endophytic Fungi. Planta Med 2016, 82 (S 01), P690. https://doi.org/10.1055/s-0036-1596741.

(14)      Patterson, A. E.; Flewelling, A. J.; Clark, T. N.; Geier, S. J.; Vogels, C. M.; Masuda, J. D.; Gray, C. A.; Westcott, S. A. Antimicrobial and Antimycobacterial Activities of Aliphatic Amines Derived from Vanillin. Can. J. Chem. 2015, 93 (11). https://doi.org/10.1139/cjc-2015-0400.

(15)      Clark, T. N.; Ellsworth, K. T.; Jean, S.; Webster, D.; Robichaud, G. A.; Johnson, J. A.; Gray, C. A. Isolation of Phomopsolide a and 6(E)-Phomopsolide a as Antimycobacterial Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum Maximum. Nat. Prod. Commun. 2015, 10 (10).

(16)      Hébert, M. J. G.; Flewelling, A. J.; Clark, T. N.; Levesque, N. A.; Jean-François, J.; Surette, M. E.; Gray, C. A.; Vogels, C. M.; Touaibia, M.; Westcott, S. A. Synthesis and Biological Activity of Arylspiroborate Salts Derived from Caffeic Acid Phenethyl Ester. Int. J. Med. Chem. 2015, 2015 (1), 418362. https://doi.org/https://doi.org/10.1155/2015/418362.

(17)      Clark, T. N.; Bishop, A. I.; McLaughlin, M.; Calhoun, L. A.; Johnson, J. A.; Gray, C. A. Isolation of (-)-Avenaciolide as the Antifungal and Antimycobacterial Constituent of a Seimatosporium Sp. Endophyte from the Medicinal Plant Hypericum Perforatum. Nat. Prod. Commun. 2014, 9 (10).

(18)      Ellsworth, K. T.; Clark, T. N.; Gray, C. A.; Johnson, J. A. Isolation and Bioassay Screening of Medicinal Plant Endophytes from Eastern Canada. Can. J. Microbiol. 2013, 59 (11), 761–765. https://doi.org/10.1139/cjm-2013-0639.

(19)      Clark, T. N.; Ellsworth, K.; Li, H.; Johnson, J. A.; Gray, C. A. Isolation of the Plant Hormone (+)-Abscisic Acid as an Antimycobacterial Constituent of the Medicinal Plant Endophyte Nigrospora Sp. Nat. Prod. Commun. 2013, 8 (12).