{"id":11,"date":"2024-12-20T14:38:14","date_gmt":"2024-12-20T18:38:14","guid":{"rendered":"https:\/\/projects.upei.ca\/trevor-clark\/?page_id=11"},"modified":"2026-07-07T14:02:25","modified_gmt":"2026-07-07T17:02:25","slug":"publications","status":"publish","type":"page","link":"https:\/\/projects.upei.ca\/trevor-clark\/publications\/","title":{"rendered":"PUBLICATIONS"},"content":{"rendered":"\n

(23) M. Maimone, N.; A. Apaza-Castillo, G.; Clark, T. N.; Perez, L. C.; Hosaka, G. K.; Delbaje, E.; Quecine, M. C.; Linington, R. G.; Lira, S. P. de. Plant Growth-Promotion and Antifungal Features of Streptomyces Sp. AM25 Unveiled by a Metabologenomics Approach. ACS Agric. Sci. Technol.<\/em> 2026<\/strong>, 6<\/em> (6), 903\u2013920. https:\/\/doi.org\/10.1021\/acsagscitech.5c01045.<\/p>\n\n\n\n

(22) Zhao, Y.; Liu, D. Y.; Clark, T. N.; Linington, R. G.; Kennelly, E. J. High-Throughput Cell Phenotype Screening Coupled with Ion Mobility Spectrometry of American Aconitum. Phytochem. Lett.<\/em> 2025<\/strong>, 69<\/em>, 103159. https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/j.phytol.2025.103159.<\/p>\n\n\n\n

(21) Zhao, Y.; Liu, D. Y.; Clark, T. N.; Linington, R. G.; Kennelly, E. J. Prediction of Bioactive Metabolites from American Aconitum Using Network Integrating Cellular Morphological Profiling and Mass Spectrometry Data. J. Nat. Prod.<\/em> 2025<\/strong>, 88<\/em> (7), 1557\u20131567. https:\/\/doi.org\/10.1021\/acs.jnatprod.4c01458.<\/p>\n\n\n\n

(20) Houriet, J.; Manwill, P. K.; Maga\u00f1a, A. A.; Anderson, V. M.; Beniddir, M. A.; Bertrand, S.; Choi, J.; Clark, T. N.; Foster, L. J.; Halabalaki, M.; Jarmusch, A. K.; de Jonge, N. F.; Khadilkar, A.; MacMillan, J. B.; Maier, C. S.; Marney, L. C.; Marti, G.; Mikropoulou, E. V; Olivier-Jimenez, D.; Perez, A.; van der Hooft, J. J. J.; Zdouc, M. M.; Linington, R. G.; Cech, N. B. Multilaboratory Untargeted Mass Spectrometry Metabolomics Collaboration to Identify Bottlenecks and Comprehensively Annotate A Single Dataset. Anal. Chem<\/em>. 2025. https:\/\/doi.org\/10.1021\/acs.analchem.4c05577.<\/p>\n\n\n\n

(19) \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Lin, F.; Recchia, M. J. J.; Clark, T. N.; Kennelly, E. J.; Linington, R. G.; Long, C. Metabolite Profiling and Characterization of Potential Anticancer Constituents from Garcinia Subfalcata Using UPLC-IMS-QTOF-MS. Food Chem.<\/em> 2025<\/strong>, 465<\/em>, 141900. https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/j.foodchem.2024.141900.<\/p>\n\n\n\n

(18)         Khadilkar, A.; Bunch, Z. L.; Wagoner, J.; Ravindran, V.; Oda, J. M.; Vidar, W. S.; Clark, T. N.; Manwill, P. K.; Todd, D. A.; Barr, S. A.; Olinger, L. K.; Fink, S. L.; Strangman, W. K.; Linington, R. G.; MacMillan, J. B.; Cech, N. B.; Polyak, S. J. Modulation of in Vitro SARS-CoV-2 Infection by Stephania Tetrandra and Its Alkaloid Constituents. J. Nat. Prod.<\/em> 2023<\/strong>, 86<\/em> (4), 1061\u20131073. https:\/\/doi.org\/10.1021\/acs.jnatprod.3c00159.<\/p>\n\n\n\n

(17)         Morehouse, N. J.; Clark, T. N.; McMann, E. J.; van Santen, J. A.; Haeckl, F. P. J.; Gray, C. A.; Linington, R. G. Annotation of Natural Product Compound Families Using Molecular Networking Topology and Structural Similarity Fingerprinting. Nat. Commun.<\/em> 2023<\/strong>, 14<\/em> (1), 308. https:\/\/doi.org\/10.1038\/s41467-022-35734-z.<\/p>\n\n\n\n

(16)         Morehouse, N. J.; Clark, T. N.; Kerr, R. G.; Johnson, J. A.; Gray, C. A. Caryophyllene Sesquiterpenes from a Chaetomium Globosum Endophyte of the Canadian Medicinal Plant Empetrum Nigrum. J. Nat. Prod.<\/em> 2023<\/strong>, 86<\/em> (6), 1615\u20131619. https:\/\/doi.org\/10.1021\/acs.jnatprod.2c01159.<\/p>\n\n\n\n

(15)         Hight, S. K.; Clark, T. N.; Kurita, K. L.; McMillan, E. A.; Bray, W.; Shaikh, A. F.; Khadilkar, A.; Haeckl, F. P. J.; Carnevale-Neto, F.; La, S.; Lohith, A.; Vaden, R. M.; Lee, J.; Wei, S.; Lokey, R. S.; White, M. A.; Linington, R. G.; MacMillan, J. B. High-Throughput Functional Annotation of Natural Products by Integrated Activity Profiling. Proc. Natl. Acad. Sci.<\/em> 2022<\/strong>, 119<\/em> (49), e2208458119. https:\/\/doi.org\/10.1073\/pnas.2208458119.<\/p>\n\n\n\n

(14)         Carnevale Neto, F.; Clark, T. N.; Lopes, N. P.; Linington, R. G. Evaluation of Ion Mobility Spectrometry for Improving Constitutional Assignment in Natural Product Mixtures. J. Nat. Prod.<\/em> 2022<\/strong>, 85<\/em> (3), 519\u2013529. https:\/\/doi.org\/10.1021\/acs.jnatprod.1c01048.<\/p>\n\n\n\n

(13)         Clark, T. N.; Houriet, J.; Vidar, W. S.; Kellogg, J. J.; Todd, D. A.; Cech, N. B.; Linington, R. G. Interlaboratory Comparison of Untargeted Mass Spectrometry Data Uncovers Underlying Causes for Variability. J. Nat. Prod.<\/em> 2021<\/strong>, 84<\/em> (3), 824\u2013835. https:\/\/doi.org\/10.1021\/acs.jnatprod.0c01376.<\/p>\n\n\n\n

(12)         van Santen, J. A.; Poynton, E. F.; Iskakova, D.; McMann, E.; Alsup, T. A.; Clark, T. N.; Fergusson, C. H.; Fewer, D. P.; Hughes, A. H.; McCadden, C. A.; Parra, J.; Soldatou, S.; Rudolf, J. D.; Janssen, E. M.-L.; Duncan, K. R.; Linington, R. G. The Natural Products Atlas 2.0: A Database of Microbially-Derived Natural Products. Nucleic Acids Res.<\/em> 2022<\/strong>, 50<\/em> (D1), D1317\u2013D1323. https:\/\/doi.org\/10.1093\/nar\/gkab941.<\/p>\n\n\n\n

(11)         Liang, L.; Haltli, B.; Marchbank, D. H.; Fischer, M.; Kirby, C. W.; Correa, H.; Clark, T. N.; Gray, C. A.; Kerr, R. G. Discovery of an Isothiazolinone-Containing Antitubercular Natural Product Levesquamide. J. Org. Chem.<\/em> 2020<\/strong>, 85<\/em> (10), 6450\u20136462. https:\/\/doi.org\/10.1021\/acs.joc.0c00339.<\/p>\n\n\n\n

(10)      Van Santen, J. A.; Jacob, G.; Singh, A. L.; Aniebok, V.; Balunas, M. J.; Bunsko, D.; Neto, F. C.; Casta\u00f1o-Espriu, L.; Chang, C.; Clark, T. N.; Cleary Little, J. L.; Delgadillo, D. A.; Dorrestein, P. C.; Duncan, K. R.; Egan, J. M.; Galey, M. M.; Haeckl, F. P. J.; Hua, A.; Hughes, A. H.; Iskakova, D.; Khadilkar, A.; Lee, J.-H.; Lee, S.; Legrow, N.; Liu, D. Y.; Macho, J. M.; McCaughey, C. S.; Medema, M. H.; Neupane, R. P.; O\u2019Donnell, T. J.; Paula, J. S.; Sanchez, L. M.; Shaikh, A. F.; Soldatou, S.; Terlouw, B. R.; Tran, T. A.; Valentine, M.; Van Der Hooft, J. J. J.; Vo, D. A.; Wang, M.; Wilson, D.; Zink, K. E.; Linington, R. G. The Natural Products Atlas: An Open Access Knowledge Base for Microbial Natural Products Discovery. ACS Cent. Sci.<\/em> 2019<\/strong>, 5<\/em> (11). https:\/\/doi.org\/10.1021\/acscentsci.9b00806. <\/p>\n\n\n\n

(9)        Clark, T. N.; Carroll, M.; Ellsworth, K.; Guerrette, R.; Robichaud, G. A.; Johnson, J. A.; Gray, C. A. Antibiotic Mycotoxins from an Endophytic Fusarium Acuminatum Isolated from the Medicinal Plant Geum Macrophyllum. Nat. Prod. Commun.<\/em> 2018<\/strong>, 13<\/em> (10).<\/p>\n\n\n\n

(8) Mullin T.; Clark T.N.; Johnson J.A.; and Gray C.A. Isolation of Phomopsolide A as the antimycobacterial constituent of an unidentified endophyte of the Canadian medicinal plant geum macrophyllum. Canadian journal of undergraduate research. February 2017<\/strong>: 69-71.<\/p>\n\n\n\n

(7)      Clark  F; Calhoun, L; Boland, P; Kerr, R; Johnson, JA; Gray, CA, T. B. A Comparison between the Application of NMR and LC-HRMS Based Metabolomics on the Discovery of Natural Products from Endophytic Fungi. Planta Med<\/em> 2016<\/strong>, 82<\/em> (S 01), P690. https:\/\/doi.org\/10.1055\/s-0036-1596741.<\/p>\n\n\n\n

(6)      Patterson, A. E.; Flewelling, A. J.; Clark, T. N.; Geier, S. J.; Vogels, C. M.; Masuda, J. D.; Gray, C. A.; Westcott, S. A. Antimicrobial and Antimycobacterial Activities of Aliphatic Amines Derived from Vanillin. Can. J. Chem.<\/em> 2015<\/strong>, 93<\/em> (11). https:\/\/doi.org\/10.1139\/cjc-2015-0400.<\/p>\n\n\n\n

(5)      Clark, T. N.; Ellsworth, K. T.; Jean, S.; Webster, D.; Robichaud, G. A.; Johnson, J. A.; Gray, C. A. Isolation of Phomopsolide a and 6(E)-Phomopsolide a as Antimycobacterial Products from an Unidentified Endophyte of the Canadian Medicinal Plant Heracleum Maximum. Nat. Prod. Commun.<\/em> 2015<\/strong>, 10<\/em> (10).<\/p>\n\n\n\n

(4)      H\u00e9bert, M. J. G.; Flewelling, A. J.; Clark, T. N.; Levesque, N. A.; Jean-Fran\u00e7ois, J.; Surette, M. E.; Gray, C. A.; Vogels, C. M.; Touaibia, M.; Westcott, S. A. Synthesis and Biological Activity of Arylspiroborate Salts Derived from Caffeic Acid Phenethyl Ester. Int. J. Med. Chem.<\/em> 2015<\/strong>, 2015<\/em> (1), 418362. https:\/\/doi.org\/https:\/\/doi.org\/10.1155\/2015\/418362.<\/p>\n\n\n\n

(3)      Clark, T. N.; Bishop, A. I.; McLaughlin, M.; Calhoun, L. A.; Johnson, J. A.; Gray, C. A. Isolation of (-)-Avenaciolide as the Antifungal and Antimycobacterial Constituent of a Seimatosporium Sp. Endophyte from the Medicinal Plant Hypericum Perforatum. Nat. Prod. Commun.<\/em> 2014<\/strong>, 9<\/em> (10).<\/p>\n\n\n\n

(2)      Ellsworth, K. T.; Clark, T. N.; Gray, C. A.; Johnson, J. A. Isolation and Bioassay Screening of Medicinal Plant Endophytes from Eastern Canada. Can. J. Microbiol.<\/em> 2013<\/strong>, 59<\/em> (11), 761\u2013765. https:\/\/doi.org\/10.1139\/cjm-2013-0639.<\/p>\n\n\n\n

(1)      Clark, T. N.; Ellsworth, K.; Li, H.; Johnson, J. A.; Gray, C. A. Isolation of the Plant Hormone (+)-Abscisic Acid as an Antimycobacterial Constituent of the Medicinal Plant Endophyte Nigrospora Sp. Nat. Prod. Commun.<\/em> 2013<\/strong>, 8<\/em> (12).<\/p>\n\n\n\n

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(23) M. Maimone, N.; A. Apaza-Castillo, G.; Clark, T. N.; Perez, L. C.; Hosaka, G. K.; Delbaje, E.; Quecine, M. C.; Linington, R. G.; Lira, S. P. de. Plant Growth-Promotion and Antifungal Features of Streptomyces Sp. AM25 Unveiled by a … Continue reading →<\/span><\/a><\/p>\n","protected":false},"author":356,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"tags":[],"_links":{"self":[{"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/pages\/11"}],"collection":[{"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/users\/356"}],"replies":[{"embeddable":true,"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/comments?post=11"}],"version-history":[{"count":4,"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/pages\/11\/revisions"}],"predecessor-version":[{"id":153,"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/pages\/11\/revisions\/153"}],"wp:attachment":[{"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/media?parent=11"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/projects.upei.ca\/trevor-clark\/wp-json\/wp\/v2\/tags?post=11"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}