Publications

Jay Penney – Google Scholar, Pubmed

  1. Penney J, Ralvenius WT, Loon A, Cerit O, Dileep V, Milo B, Pao PC, Woolf H, Tsai LH. (2024). iPSC-derived microglia carrying the TREM2 R47H/+ mutation are proinflammatory and promote synapse loss. Glia. 72(2): 452-469. doi: 10.1002/glia.24485
  2. Ralvenius WT, Andresen JL, Huston MM, Penney J, Bonner JM, Fenton OS, Langer R, Tsai LH. (2023). Nanoparticle-mediated Delivery of Anti-PU.1 Sirna via Localized Intracisternal Administration Reduces Neuroinflammation. Advanced Materials. Online ahead of print. doi: 10.1002/adma.202309225
  3. Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, Marcora E, Romero-Molina C, Ayata P, Schaefer A, Gjoneska E, Tsai LH. (2023). A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. Journal of Experimental Medicine. 220(11): e20222105. doi: 10.1084/jem.20222105
  4. Pao PC, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, Raju RM, Geigenmuller U, Silva MC, Lucente DE, Gusella JF, Dickerson BC, Loon A, Yu MX, Bula M, Yu M, Haggarty SJ, Tsai LH. (2023). A Cdk5-derived peptide inhibits Cdk5/p25 activity and improves neurodegenerative phenotypes. Proceedings of the National Academy of Sciences U S A. 120(16): e2217864120. doi: 10.1073/pnas.2217864120
  5. Mori M, Penney J, Haghighi AP. (2021). Regulation of synaptic homeostasis by translational mechanisms. Oxford Handbook of Neuronal Protein Synthesis. Ed. Sossin WS. Oxford University Press. doi:10.1093/oxfordhb/9780190686307.001.0001
  6. Penney J, Ralvenius WT, Tsai LH. (2020). Modeling Alzheimer’s disease with iPSC-derived brain cells. Molecular Psychiatry. 25(1): 148-167. doi: 10.1038/s41380-019-0468-3
  7. Morshed N, Ralvenius WT, Nott A, Watson LA, Rodrigues FH, Akay LA, Joughin B, Pao PC, Penney J, LaRocque L, Mastroeni D, Tsai LH, White FM. (2020). Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration. Molecular Systems Biology. 16(12): e9819. doi: 10.15252/msb.20209819
  8. Pao PC, Patniak D, Watson LA, Gao F, Pan L, Wang J, Adaikkan C, Penney J, Cam HP, Wang WC, Pantano L, Lee A, Nott A, Phan TX, Gjoneska E, Elmsaouri S, Haggarty SJ, Tsai LH. (2020). HDAC1 modulates OGG1-initiated oxidative DNA damage repair, brain aging, and Alzheimer’s disease pathology. Nature Communications. 11(1): 2484. doi: 10.1038/s41467-020-16361-y
  9. Pao PC, Penney J, Tsai LH. (2019). Examining the role of HDACs in DNA double-strand break repair in neurons. In: Brosh, Jr. R. (eds) Protein Acetylation. Methods in Molecular Biology, vol 1983: 225-234. Humana, New York, NY. doi: 10.1007/978-1-4939-9434-2_13
  10. Penney J, Tsai LH. (2018). Elimination of senescent cells prevents neurodegeneration in mice. Nature. 562(7728): 503-504. doi: 10.1038/d41586-018-06677-7
  11. Lin YT, Seo J, Gao F, Feldman HM, Wen HL, Penney J, Cam HP, Gjoneska E, Raja WK, Cheng J, Rueda R, Kritskiy O, Abdurrob F, Peng Z, Milo B, Yu CJ, Elmsaouri S, Dey D, Ko T, Yankner BA, Tsai LH. (2018). APOE4 causes widespread molecular and cellular alterations associated with Alzheimer’s disease phenotypes in human iPSC-derived brain cell types. Neuron. 98(6): 1141-1154. doi: 10.1016/j.neuron.2018.05.008
  12. Mathys H, Penney J, Tsai LH. (2018). A developmental switch in microglia HDAC function. Immunity. 48(3): 476-478. doi: 10.1016/j.immuni.2018.03.010
  13. Penney J, Seo J, Kritskiy O, Elmsaouri S, Gao F, Pao PC, Su SC, Tsai LH. (2017). Loss of protein arginine methyltransferase 8 alters synapse composition and function, resulting in behavioral defects. Journal of Neuroscience. 37(36): 8655-8666. doi: 10.1523/JNEUROSCI.0591-17.2017
  14. Yamakawa H*, Cheng J*, Penney J*, Gao F, Rueda R, Wang J, Yamakawa S, Kritskiy O, Gjoneska E, Tsai LH. (2017). The transcription factor Sp3 cooperates with HDAC2 to regulate synaptic function and plasticity in neurons. Cell Reports. 20(6): 1319-1334. doi: 10.1016/j.celrep.2017.07.044 *equal contribution
  15. Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T, Cho S, Penney J, Silva MC, Sheridan SD, Lucente D, Gusella JF, Dickerson BC, Haggarty SJ, Tsai LH. (2017). Inhibition of p25/Cdk5 attenuates tauopathy in mouse and iPSC models of frontotemporal dementia. Journal of Neuroscience. 37(41): 9917-9924. doi: 10.1523/JNEUROSCI.0621-17.2017
  16. Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, Calderon MR, Sonenberg N, Haghighi AP. (2016). LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nature Communications. 7: 12188. doi: 10.1038/ncomms12188
  17. Canter RG, Penney J, Tsai LH. (2016). The road to restoring neural circuits for the treatment of Alzheimer’s disease. Nature. 539(7628): 187-196. doi: 10.1038/nature20412
  18. Kauwe G, Tsurudome K, Penney J, Mori M, Gray L, Calderon MR, Elazouzzi F, Chicoine N, Sonenberg N, Haghighi AP. (2016). Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism. Neuron. 92(6): 1204-1212. doi: 10.1016/j.neuron.2016.10.063
  19. Penney J, Tsai LH. (2015). JAKMIP1: Translating the Message for Social Behavior. Neuron. 88(6): 1070-2. doi: 10.1016/j.neuron.2015.12.003
  20. Penney J, Tsai LH. (2014). Histone deacetylases in memory and cognition. Science Signaling. 7(355):re12: 1-8. doi: 10.1126/scisignal.aaa0069
  21. Pan L, Penney J, Tsai LH. (2014). Chromatin regulation of DNA damage repair and genome integrity in the central nervous system. Journal of Molecular Biology. 426(20): 3376-88. doi: 10.1016/j.jmb.2014.08.001
  22. Penney J, Tsurudome K, Liao EH, Elazzouzi F, Livingstone M, Gonzalez M, Sonenberg N and Haghighi AP. (2012). TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron. 74(1): 166-78. doi: 10.1016/j.neuron.2012.01.030
  23. Tsurudome K, Tsang K, Liao EH, Ball R, Penney J, Yang JS, Elazzouzi F, He T, Chishti A, Lnenicka G, Lai EC, Haghighi AP. (2010). The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction. Neuron. 68(5): 879-93. doi: 10.1016/j.neuron.2010.11.016
  24. Merino C, Penney J, Gonzalez M, Moujahidine M, O’Connor MB, Verheyen EM and Haghighi P. (2009). Nemo kinase interacts with Mad to coordinate synaptic growth at the Drosophila NMJ. Journal of Cell Biology. 185(4): 713-725. doi: 10.1083/jcb.200809127
  25. Penney J, Bossé J and Clark DV. (2008). Expression pattern diversity and functional conservation between retroposed PRAT genes from Drosophila melanogaster and Drosophila virilis. Journal of Molecular Evolution. 66(5): 457-71. doi: 10.1007/s00239-008-9098-0