Our understanding of immune cell metabolism (e.g. T cell and macrophage subsets) is constantly increasing. We continue to gain a deeper appreciation for production of “immunometabolites” such as itaconate and succinate, their function, and how they change during the differentiation of immune cell subsets^1,2. Our lab is interested in exploring the function of these immunometabolites and other intermediates of secondary metabolic pathways commonly found to be regulated in macrophages and other immune cells.  

1. Giacomantio MA, Sterea AM, Kim Y, Paulo JA, Clements DR, Kennedy BE, Bydoun MJ, Waisman DM, Gygi SP, Giacomantonio CA, Murphy JP^##, Gujar S^##. (2020). Quantitative proteome responses to oncolytic reovirus in GM-CSF and M-CSF-differentiated bone marrow-derived cells. J. Proteome Res. 19(2):708-718.
2. Clements D, Murphy JP, Sterea A, Kennedy BE, Kim Y, Helson E, Almasi S, Holay N, Konda P, Paulo JA, Sharif T, Lee PW, Weekes MP, Gygi SP, Gujar S. (2017). Quantitative temporal in vivo proteomics deciphers the transition of virus-driven myeloid cells into M2 macrophages. J. Proteome Res.16(9): 3391-3406.